THERAPEUTIC TARGETING OF ALTERNATIVE SPLICING

Therapeutic targeting of alternative splicing

Gene transcription leads to the generation of pre-mRNA molecules which contain both coding sequences (exons) and intervening non-coding sequences (introns).The primary transcript needs further processing which involves the excision of introns and ligation of exons.This process is called RNA splicing.Nearly all primary transcripts undergo alternativ

read more

Real Time Kinematic (RTK) heave as a replacement of Motion Reference Unit (MRU) heave in hydrographic surveying works

Heave is one of the major contributors to errors in water depth measurements.Motion Reference Unit (MRU) measures the heave signal with high-level accuracy as well as other ship motions.Unfortunately, MRU has been reported to have some of drawbacks such as; heave drift error, influence of ship motion dynamic, In addition to its very expensive price

read more


Optimal Allocation of Phasor Measurement Units Using Particle Swarm Optimization: An Electric Grid Planning Perspective

In this paper, the particle swarm optimization (PSO) technique is used to optimally allocate phasor measurement units (PMUs) within standard test systems and a real-world power system.PMUs are allocated at system substations in a manner that ensures complete system observability while minimizing installation costs.This study considers IEEE 14-, 30-

read more